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Neutrophil P2X(7) receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
Although extracellular ATP is abundant at sites of inflammation, its role in activating inflammasome signalling in neutrophils is not well characterized. In the current study, we demonstrate that human and murine neutrophils express functional cell-surface P2X(7)R, which leads to ATP-induced loss of...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4756306/ https://ncbi.nlm.nih.gov/pubmed/26877061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10555 |
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