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IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and Caspase-1()
To examine the role of caspase-1 and the NLRC4 inflammasome during bacterial infection, C57BL/6, IL-1β(−/−), Caspase-1(−/−), and NLRC4(−/−) mouse corneas were infected with ExoS/T or ExoU expressing Pseudomonas aeruginosa. We found that IL-1β was essential for neutrophil recruitment and bacterial cl...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482477/ https://ncbi.nlm.nih.gov/pubmed/23024281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201447 |
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