An Advanced Preclinical Mouse Model for Acute Myeloid Leukemia Using Patients' Cells of Various Genetic Subgroups and In Vivo Bioluminescence Imaging

Acute myeloid leukemia (AML) is a clinically and molecularly heterogeneous disease with poor outcome. Adequate model systems are required for preclinical studies to improve understanding of AML biology and to develop novel, rational treatment approaches. Xenografts in immunodeficient mice allow perf...

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Udgivet i:PLoS One
Main Authors: Vick, Binje, Rothenberg, Maja, Sandhöfer, Nadine, Carlet, Michela, Finkenzeller, Cornelia, Krupka, Christina, Grunert, Michaela, Trumpp, Andreas, Corbacioglu, Selim, Ebinger, Martin, André, Maya C., Hiddemann, Wolfgang, Schneider, Stephanie, Subklewe, Marion, Metzeler, Klaus H., Spiekermann, Karsten, Jeremias, Irmela
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4368518/
https://ncbi.nlm.nih.gov/pubmed/25793878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120925
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