Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

The fms-related tyrosine kinase 3 (FLT3) receptor has been extensively studied over the past two decades with regard to oncogenic alterations that do not only serve as prognostic markers but also as therapeutic targets in acute myeloid leukemia (AML). Internal tandem duplications (ITDs) became of sp...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Reiter, K, Polzer, H, Krupka, C, Maiser, A, Vick, B, Rothenberg-Thurley, M, Metzeler, K H, Dörfel, D, Salih, H R, Jung, G, Nößner, E, Jeremias, I, Hiddemann, W, Leonhardt, H, Spiekermann, K, Subklewe, M, Greif, P A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808080/
https://ncbi.nlm.nih.gov/pubmed/28895560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.257
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