The new and recurrent FLT3 juxtamembrane deletion mutation shows a dominant negative effect on the wild-type FLT3 receptor

In acute myeloid leukemia (AML), the Fms-like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes. Recently, a new and recurrent juxtamembrane deletion mutation (p.Q569Vfs*2) resulting in a truncated receptor was identified. The mutated receptor is expressed on the cell surface and...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Sandhöfer, Nadine, Bauer, Julia, Reiter, Katrin, Dufour, Annika, Rothenberg, Maja, Konstandin, Nikola P., Zellmeier, Evelyn, Tizazu, Belay, Greif, Philipp A., Metzeler, Klaus H., Hiddemann, Wolfgang, Polzer, Harald, Spiekermann, Karsten
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921855/
https://ncbi.nlm.nih.gov/pubmed/27346558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28032
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