Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

Some patients with acute myeloid leukemia (AML) who are in complete remission after induction chemotherapy harbor persisting pre-leukemic clones, carrying a subset of leukemia-associated somatic mutations. There is conflicting evidence on the prognostic relevance of these clones for AML relapse. Her...

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Pubblicato in:Leukemia
Autori principali: Rothenberg-Thurley, Maja, Amler, Susanne, Goerlich, Dennis, Köhnke, Thomas, Konstandin, Nikola P., Schneider, Stephanie, Sauerland, Maria C., Herold, Tobias, Hubmann, Max, Ksienzyk, Bianka, Zellmeier, Evelyn, Bohlander, Stefan K., Subklewe, Marion, Faldum, Andreas, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten, Metzeler, Klaus H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6035153/
https://ncbi.nlm.nih.gov/pubmed/29472724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0034-z
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