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Processing by Convertases Is Required for Glypican-3-induced Inhibition of Hedgehog Signaling

Glypican-3 (GPC3) is one of the six members of the mammalian glypican family. We have previously reported that GPC3 inhibits Hedgehog (Hh) signaling by competing with Patched (Ptc) for Hh binding. We also showed that GPC3 binds with high affinity to Hh through its core protein, but that it does not...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Capurro, Mariana, Shi, Wen, Izumikawa, Tomomi, Kitagawa, Hiroshi, Filmus, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367263/
https://ncbi.nlm.nih.gov/pubmed/25653284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612705
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