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Processing by Convertases Is Required for Glypican-3-induced Inhibition of Hedgehog Signaling
Glypican-3 (GPC3) is one of the six members of the mammalian glypican family. We have previously reported that GPC3 inhibits Hedgehog (Hh) signaling by competing with Patched (Ptc) for Hh binding. We also showed that GPC3 binds with high affinity to Hh through its core protein, but that it does not...
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| Gepubliceerd in: | J Biol Chem |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Biochemistry and Molecular Biology
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4367263/ https://ncbi.nlm.nih.gov/pubmed/25653284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612705 |
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