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LRP1 mediates Hedgehog-induced endocytosis of the GPC3–Hedgehog complex
Glypican-3 (GPC3) is a heparan sulfate (HS) proteoglycan that is bound to the cell membrane through a glycosylphosphatidylinositol link. This glypican regulates embryonic growth by inhibiting the hedgehog (Hh) signaling pathway. GPC3 binds Hh and competes with Patched (Ptc), the Hh receptor, for Hh...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3843007/ https://ncbi.nlm.nih.gov/pubmed/22467855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.098889 |
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