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Processing by Convertases Is Required for Glypican-3-induced Inhibition of Hedgehog Signaling
Glypican-3 (GPC3) is one of the six members of the mammalian glypican family. We have previously reported that GPC3 inhibits Hedgehog (Hh) signaling by competing with Patched (Ptc) for Hh binding. We also showed that GPC3 binds with high affinity to Hh through its core protein, but that it does not...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4367263/ https://ncbi.nlm.nih.gov/pubmed/25653284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.612705 |
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