Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling

Autosomal-recessive omodysplasia (OMOD1) is a genetic condition characterized by short stature, shortened limbs, and facial dysmorphism. OMOD1 is caused by loss-of-function mutations of glypican 6 (GPC6). In this study, we show that GPC6-null embryos display most of the abnormalities found in OMOD1...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Capurro, Mariana, Izumikawa, Tomomi, Suarez, Philippe, Shi, Wen, Cydzik, Marzena, Kaneiwa, Tomoyuki, Gariepy, Jean, Bonafe, Luisa, Filmus, Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584141/
https://ncbi.nlm.nih.gov/pubmed/28696225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201605119
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