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Deregulation of DNA Double-Strand Break Repair in Multiple Myeloma: Implications for Genome Stability

Multiple myeloma (MM) is a hematological malignancy characterized by frequent chromosome abnormalities. However, the molecular basis for this genome instability remains unknown. Since both impaired and hyperactive double strand break (DSB) repair pathways can result in DNA rearrangements, we investi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Herrero, Ana B., San Miguel, Jesús, Gutierrez, Norma C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366222/
https://ncbi.nlm.nih.gov/pubmed/25790254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121581
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