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Deregulation of DNA Double-Strand Break Repair in Multiple Myeloma: Implications for Genome Stability

Multiple myeloma (MM) is a hematological malignancy characterized by frequent chromosome abnormalities. However, the molecular basis for this genome instability remains unknown. Since both impaired and hyperactive double strand break (DSB) repair pathways can result in DNA rearrangements, we investi...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Herrero, Ana B., San Miguel, Jesús, Gutierrez, Norma C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366222/
https://ncbi.nlm.nih.gov/pubmed/25790254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121581
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