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Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity
μ-Conotoxins block voltage-gated sodium channels (VGSCs) and compete with tetrodotoxin for binding to the sodium conductance pore. Early efforts identified μ-conotoxins that preferentially blocked the skeletal muscle subtype (Na(V)1.4). However, the last decade witnessed a significant increase in th...
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| I publikationen: | Future Med Chem |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4366142/ https://ncbi.nlm.nih.gov/pubmed/25406007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.14.107 |
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