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Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity

μ-Conotoxins block voltage-gated sodium channels (VGSCs) and compete with tetrodotoxin for binding to the sodium conductance pore. Early efforts identified μ-conotoxins that preferentially blocked the skeletal muscle subtype (Na(V)1.4). However, the last decade witnessed a significant increase in th...

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Bibliografske podrobnosti
izdano v:Future Med Chem
Main Authors: Green, Brad R, Bulaj, Grzegorz, Norton, Raymond S
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366142/
https://ncbi.nlm.nih.gov/pubmed/25406007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.14.107
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