Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

Plumbagin (PLB) has been shown to have anticancer activities in animal models, but the role of PLB in prostate cancer treatment is unclear. This study aimed to investigate the effects of PLB on apoptosis and autophagy and the underlying mechanisms in human prostate cancer cell lines PC-3 and DU145....

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Dades bibliogràfiques
Publicat a:Drug Des Devel Ther
Autors principals: Zhou, Zhi-Wei, Li, Xing-Xiao, He, Zhi-Xu, Pan, Shu-Ting, Yang, Yinxue, Zhang, Xueji, Chow, Kevin, Yang, Tianxin, Qiu, Jia-Xuan, Zhou, Qingyu, Tan, Jun, Wang, Dong, Zhou, Shu-Feng
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366042/
https://ncbi.nlm.nih.gov/pubmed/25834399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S75976
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