Plumbagin induces G(2)/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone; PLB), a naturally occurring naphthoquinone isolated from the roots of Plumbaginaceae plants, has been reported to possess anticancer activities in both in vitro and in vivo studies, but the effect of PLB on tongue squamous cell carcinoma (TSCC) is no...

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Bibliografische gegevens
Gepubliceerd in:Drug Des Devel Ther
Hoofdauteurs: Pan, Shu-Ting, Qin, Yiru, Zhou, Zhi-Wei, He, Zhi-Xu, Zhang, Xueji, Yang, Tianxin, Yang, Yin-Xue, Wang, Dong, Qiu, Jia-Xuan, Zhou, Shu-Feng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Dove Medical Press 2015
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Original Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365758/
https://ncbi.nlm.nih.gov/pubmed/25834400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S76057
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