Plumbagin induces G(2)/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone; PLB), a naturally occurring naphthoquinone isolated from the roots of Plumbaginaceae plants, has been reported to possess anticancer activities in both in vitro and in vivo studies, but the effect of PLB on tongue squamous cell carcinoma (TSCC) is no...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Des Devel Ther
Prif Awduron: Pan, Shu-Ting, Qin, Yiru, Zhou, Zhi-Wei, He, Zhi-Xu, Zhang, Xueji, Yang, Tianxin, Yang, Yin-Xue, Wang, Dong, Qiu, Jia-Xuan, Zhou, Shu-Feng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Dove Medical Press 2015
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365758/
https://ncbi.nlm.nih.gov/pubmed/25834400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S76057
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