Alisertib induces G(2)/M arrest, apoptosis, and autophagy via PI3K/Akt/mTOR- and p38 MAPK-mediated pathways in human glioblastoma cells

Glioblastoma (GBM) is the most common brain tumor with poor response to current therapeutics. Alisertib (ALS), a second-generation selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects on solid tumors in animal studies. This study aimed to investigate the killing effect of...

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Detalhes bibliográficos
Publicado no:Am J Transl Res
Main Authors: Liu, Zheng, Wang, Feng, Zhou, Zhi-Wei, Xia, He-Chun, Wang, Xin-Yu, Yang, Yin-Xue, He, Zhi-Xu, Sun, Tao, Zhou, Shu-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375982/
https://ncbi.nlm.nih.gov/pubmed/28386317
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