Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells

Pancreatic cancer is the most aggressive cancer worldwide with poor response to current therapeutics. Alisertib (ALS), a potent and selective Aurora kinase A inhibitor, exhibits potent anticancer effects in preclinical and clinical studies; however, the effect and underlying mechanism of ALS in the...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Wang, Feng, Li, Hai, Yan, Xiao-Gang, Zhou, Zhi-Wei, Yi, Zhi-Gang, He, Zhi-Xu, Pan, Shu-Ting, Yang, Yin-Xue, Wang, Zuo-Zheng, Zhang, Xueji, Yang, Tianxing, Qiu, Jia-Xuan, Zhou, Shu-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304576/
https://ncbi.nlm.nih.gov/pubmed/25632225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S75221
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