Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells

Plumbagin (PLB), an active naphthoquinone compound, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of PLB for the treatment of pancreatic cancer is unclear. This study aimed to examine the pancreatic cancer cell killing effect of PLB and inve...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Drug Des Devel Ther
Main Authors: Wang, Feng, Wang, Qi, Zhou, Zhi-Wei, Yu, Song-Ning, Pan, Shu-Ting, He, Zhi-Xu, Zhang, Xueji, Wang, Dong, Yang, Yin-Xue, Yang, Tianxing, Sun, Tao, Li, Min, Qiu, Jia-Xuan, Zhou, Shu-Feng
פורמט: Artigo
שפה:Inglês
יצא לאור: Dove Medical Press 2015
נושאים:
Original Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304578/
https://ncbi.nlm.nih.gov/pubmed/25632222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S73689
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