Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human

PERK, PKR, HRI and GCN2 are the four mammalian kinases that phosphorylate the α subunit of the eukaryotic translation initiation factor 2 (eIF2α) on Ser51. This phosphorylation event is conserved among many species and attenuates protein synthesis in response to diverse stress conditions. In contras...

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Publicat a:Int J Biochem Cell Biol
Autors principals: Majumder, Mithu, Mitchell, Daniel, Merkulov, Sergei, Wu, Jing, Guan, Bo-Jhih, Snider, Martin D., Krokowski, Dawid, Yee, Vivien C., Hatzoglou, Maria
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365977/
https://ncbi.nlm.nih.gov/pubmed/25541374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2014.12.004
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