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A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers transcriptional and translational reprogramming. This unfolded protein response (UPR) protects cells during transient stress and can lead to apoptosis during prolonged stress. Two key mediators of the UPR are PKR-like E...

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Bibliografiske detaljer
Main Authors: Majumder, Mithu, Huang, Charlie, Snider, Martin D., Komar, Anton A., Tanaka, Junichi, Kaufman, Randal J., Krokowski, Dawid, Hatzoglou, Maria
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295193/
https://ncbi.nlm.nih.gov/pubmed/22215619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06665-11
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