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A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers transcriptional and translational reprogramming. This unfolded protein response (UPR) protects cells during transient stress and can lead to apoptosis during prolonged stress. Two key mediators of the UPR are PKR-like E...

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Main Authors: Majumder, Mithu, Huang, Charlie, Snider, Martin D., Komar, Anton A., Tanaka, Junichi, Kaufman, Randal J., Krokowski, Dawid, Hatzoglou, Maria
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295193/
https://ncbi.nlm.nih.gov/pubmed/22215619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06665-11
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