A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux

Endoplasmic reticulum (ER) stress-induced responses are associated with the loss of insulin-producing β-cells in type 2 diabetes mellitus. β-Cell survival during ER stress is believed to depend on decreased protein synthesis rates that are mediated via phosphorylation of the translation initiation f...

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Detalhes bibliográficos
Main Authors: Krokowski, Dawid, Han, Jaeseok, Saikia, Mridusmita, Majumder, Mithu, Yuan, Celvie L., Guan, Bo-Jhih, Bevilacqua, Elena, Bussolati, Ovidio, Bröer, Stefan, Arvan, Peter, Tchórzewski, Marek, Snider, Martin D., Puchowicz, Michelle, Croniger, Colleen M., Kimball, Scot R., Pan, Tao, Koromilas, Antonis E., Kaufman, Randal J., Hatzoglou, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682525/
https://ncbi.nlm.nih.gov/pubmed/23645676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.466920
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