Novel 4-Substituted-N,N-dimethyltetrahydronaphthalen-2-amines: Synthesis, Affinity, and In Silico Docking Studies at Serotonin 5-HT2-type and Histamine H(1) G Protein-Coupled Receptors

Syntheses were undertaken of derivatives of (2S, 4R)-(−)-trans-4-phenyl-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine (4-phenyl-2-dimethylaminotetralin, PAT), a stereospecific agonist at the serotonin 5-HT(2C) G protein-coupled receptor (GPCR), with inverse agonist activity at 5-HT(2A) and 5-HT(...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Sakhuja, Rajeev, Kondabolu, Krishnakanth, Córdova-Sintjago, Tania, Travers, Sean, Vincek, Adam S., Kim, Myong Sang, Abboud, Khalil A., Fang, Lijuan, Sun, Zhuming, Canal, Clinton E., Booth, Raymond G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363177/
https://ncbi.nlm.nih.gov/pubmed/25703249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.060
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