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Molecular Determinants for Ligand Binding at Serotonin 5-HT(2A) and 5-HT(2C) GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies
Ligands that activate the serotonin 5-HT(2C) G protein-coupled receptor (GPCR) may be therapeutic for psychoses, addiction, and other neuropsychiatric disorders. Ligands that are antagonists at the closely related 5-HT(2A) GPCR also may treat neuropsychiatric disorders; in contrast, 5-HT(2A) activat...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3729958/ https://ncbi.nlm.nih.gov/pubmed/23913978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/qua.24237 |
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