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Molecular Determinants for Ligand Binding at Serotonin 5-HT(2A) and 5-HT(2C) GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies

Ligands that activate the serotonin 5-HT(2C) G protein-coupled receptor (GPCR) may be therapeutic for psychoses, addiction, and other neuropsychiatric disorders. Ligands that are antagonists at the closely related 5-HT(2A) GPCR also may treat neuropsychiatric disorders; in contrast, 5-HT(2A) activat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Córdova-Sintjago, Tania, Sakhuja, Rajeev, Kondabolu, Krishnakanth, Canal, Clinton E., Booth, Raymond G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729958/
https://ncbi.nlm.nih.gov/pubmed/23913978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/qua.24237
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