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Molecular Determinants for Ligand Binding at Serotonin 5-HT(2A) and 5-HT(2C) GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies

Ligands that activate the serotonin 5-HT(2C) G protein-coupled receptor (GPCR) may be therapeutic for psychoses, addiction, and other neuropsychiatric disorders. Ligands that are antagonists at the closely related 5-HT(2A) GPCR also may treat neuropsychiatric disorders; in contrast, 5-HT(2A) activat...

詳細記述

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書誌詳細
主要な著者: Córdova-Sintjago, Tania, Sakhuja, Rajeev, Kondabolu, Krishnakanth, Canal, Clinton E., Booth, Raymond G.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729958/
https://ncbi.nlm.nih.gov/pubmed/23913978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/qua.24237
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