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Novel 4-Substituted-N,N-dimethyltetrahydronaphthalen-2-amines: Synthesis, Affinity, and In Silico Docking Studies at Serotonin 5-HT2-type and Histamine H(1) G Protein-Coupled Receptors
Syntheses were undertaken of derivatives of (2S, 4R)-(−)-trans-4-phenyl-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine (4-phenyl-2-dimethylaminotetralin, PAT), a stereospecific agonist at the serotonin 5-HT(2C) G protein-coupled receptor (GPCR), with inverse agonist activity at 5-HT(2A) and 5-HT(...
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| Опубликовано в: : | Bioorg Med Chem |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4363177/ https://ncbi.nlm.nih.gov/pubmed/25703249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.060 |
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