Novel 4-Substituted-N,N-dimethyltetrahydronaphthalen-2-amines: Synthesis, Affinity, and In Silico Docking Studies at Serotonin 5-HT2-type and Histamine H(1) G Protein-Coupled Receptors

Syntheses were undertaken of derivatives of (2S, 4R)-(−)-trans-4-phenyl-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine (4-phenyl-2-dimethylaminotetralin, PAT), a stereospecific agonist at the serotonin 5-HT(2C) G protein-coupled receptor (GPCR), with inverse agonist activity at 5-HT(2A) and 5-HT(...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Bioorg Med Chem
Autores principales: Sakhuja, Rajeev, Kondabolu, Krishnakanth, Córdova-Sintjago, Tania, Travers, Sean, Vincek, Adam S., Kim, Myong Sang, Abboud, Khalil A., Fang, Lijuan, Sun, Zhuming, Canal, Clinton E., Booth, Raymond G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4363177/
https://ncbi.nlm.nih.gov/pubmed/25703249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.060
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares