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Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: potential utility as antipsychotic medications

BACKGROUND: Desired serotonin 5HT2 receptor pharmacology for treatment of psychoses is 5HT2A antagonism and/or 5HT2C agonism. No selective 5HT2A antagonist has been approved for psychosis and the only approved 5HT2C agonist (for obesity) also activates 5HT2A and 5HT2B receptors, which can lead to cl...

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Bibliografiske detaljer
Main Authors: Morgan, Drake, Kondabolu, Krishnakanth, Kuipers, Allison, Sakhuja, Rajeev, Robertson, Kimberly L., Rowland, Neil E., Booth, Raymond G.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696402/
https://ncbi.nlm.nih.gov/pubmed/23665356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.04.051
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