Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection

Invasive pulmonary aspergillosis is a leading cause of infection-associated mortality in immunocompromised individuals. Aspergillus fumigatus infection produces ligands that could activate inflammasomes but the contribution of these host defenses remains unclear. We show that two inflammasome recept...

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Vydáno v:Cell Host Microbe
Hlavní autoři: Karki, Rajendra, Man, Si Ming, Malireddi, R.K. Subbarao, Gurung, Prajwal, Vogel, Peter, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359672/
https://ncbi.nlm.nih.gov/pubmed/25704009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.01.006
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