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Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection

Invasive pulmonary aspergillosis is a leading cause of infection-associated mortality in immunocompromised individuals. Aspergillus fumigatus infection produces ligands that could activate inflammasomes but the contribution of these host defenses remains unclear. We show that two inflammasome recept...

Полное описание

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Библиографические подробности
Опубликовано в: :Cell Host Microbe
Главные авторы: Karki, Rajendra, Man, Si Ming, Malireddi, R.K. Subbarao, Gurung, Prajwal, Vogel, Peter, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359672/
https://ncbi.nlm.nih.gov/pubmed/25704009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.01.006
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