Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells

Approximately half of poor prognosis neuroblastomas (NBs) are characterized by pathognomonic MYCN gene amplification and MYCN over‐expression. Here we present data showing that short‐interfering RNA mediated depletion of the protein arginine methyltransferase 5 (PRMT5) in cell‐lines representative o...

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Vydáno v:Mol Oncol
Hlavní autoři: Park, Ji Hyun, Szemes, Marianna, Vieira, Gabriella Cunha, Melegh, Zsombor, Malik, Sally, Heesom, Kate J., Von Wallwitz-Freitas, Laura, Greenhough, Alexander, Brown, Keith W., Zheng, Y. George, Catchpoole, Daniel, Deery, Michael J., Malik, Karim
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2014
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359099/
https://ncbi.nlm.nih.gov/pubmed/25475372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.10.015
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