Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells

Approximately half of poor prognosis neuroblastomas (NBs) are characterized by pathognomonic MYCN gene amplification and MYCN over‐expression. Here we present data showing that short‐interfering RNA mediated depletion of the protein arginine methyltransferase 5 (PRMT5) in cell‐lines representative o...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Oncol
Main Authors: Park, Ji Hyun, Szemes, Marianna, Vieira, Gabriella Cunha, Melegh, Zsombor, Malik, Sally, Heesom, Kate J., Von Wallwitz-Freitas, Laura, Greenhough, Alexander, Brown, Keith W., Zheng, Y. George, Catchpoole, Daniel, Deery, Michael J., Malik, Karim
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2014
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359099/
https://ncbi.nlm.nih.gov/pubmed/25475372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.10.015
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