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Alternative Lengthening of Telomeres Renders Cancer Cells Hypersensitive to ATR Inhibitors

Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human cancers, yet whether it can be exploited therapeutically remains unknown. Loss of the chromatin remodeli...

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Bibliographische Detailangaben
Veröffentlicht in:Science
Hauptverfasser: Flynn, Rachel Litman, Cox, Kelli E., Jeitany, Maya, Wakimoto, Hiroaki, Bryll, Alysia R., Ganem, Neil J., Bersani, Francesca, Pineda, Jose R., Suvà, Mario L., Benes, Cyril H., Haber, Daniel A., Boussin, Francois D., Zou, Lee
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358324/
https://ncbi.nlm.nih.gov/pubmed/25593184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1257216
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