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Alternative Lengthening of Telomeres Renders Cancer Cells Hypersensitive to ATR Inhibitors
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human cancers, yet whether it can be exploited therapeutically remains unknown. Loss of the chromatin remodeli...
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| Veröffentlicht in: | Science |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4358324/ https://ncbi.nlm.nih.gov/pubmed/25593184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1257216 |
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