Alternative Lengthening of Telomeres Renders Cancer Cells Hypersensitive to ATR Inhibitors

Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human cancers, yet whether it can be exploited therapeutically remains unknown. Loss of the chromatin remodeli...

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Pubblicato in:Science
Autori principali: Flynn, Rachel Litman, Cox, Kelli E., Jeitany, Maya, Wakimoto, Hiroaki, Bryll, Alysia R., Ganem, Neil J., Bersani, Francesca, Pineda, Jose R., Suvà, Mario L., Benes, Cyril H., Haber, Daniel A., Boussin, Francois D., Zou, Lee
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358324/
https://ncbi.nlm.nih.gov/pubmed/25593184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1257216
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