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APOBEC3A and 3B Activities Render Cancer Cells Susceptible to ATR Inhibition
The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and 3B have emerged as key mutation drivers in cancer. Here we show that APOBEC3A and 3B activities impose a unique type of replication stress by inducing abasic sites at replication forks. In contrast to cells under other...
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| Udgivet i: | Cancer Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5609510/ https://ncbi.nlm.nih.gov/pubmed/28698210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3389 |
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