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Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition

Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular immortality. A significant fraction of tumors uses the alternative lengthening of telomeres (ALT) pathway to elongate their telomeres and to gain an unlimited proliferation potential. Since the ALT pathway is uniq...

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Bibliografische gegevens
Gepubliceerd in:Front Oncol
Hoofdauteurs: Deeg, Katharina I., Chung, Inn, Bauer, Caroline, Rippe, Karsten
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993795/
https://ncbi.nlm.nih.gov/pubmed/27602331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2016.00186
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