Alternative lengthening of telomeres: remodeling the telomere architecture

To escape from the normal limits on proliferative potential, cancer cells must employ a means to counteract the gradual telomere attrition that accompanies semi-conservative DNA replication. While the majority of human cancers do this by up-regulating telomerase enzyme activity, most of the remainde...

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Main Authors: Conomos, Dimitri, Pickett, Hilda A., Reddel, Roger R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576624/
https://ncbi.nlm.nih.gov/pubmed/23429284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00027
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https://ncbi.nlm.nih.gov/pmc/articles/PMC3576624/
https://ncbi.nlm.nih.gov/pubmed/23429284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00027