Alternative Lengthening of Telomeres Renders Cancer Cells Hypersensitive to ATR Inhibitors

Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human cancers, yet whether it can be exploited therapeutically remains unknown. Loss of the chromatin remodeli...

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Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Flynn, Rachel Litman, Cox, Kelli E., Jeitany, Maya, Wakimoto, Hiroaki, Bryll, Alysia R., Ganem, Neil J., Bersani, Francesca, Pineda, Jose R., Suvà, Mario L., Benes, Cyril H., Haber, Daniel A., Boussin, Francois D., Zou, Lee
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358324/
https://ncbi.nlm.nih.gov/pubmed/25593184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1257216
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