Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion

Cytotoxic T cells (Tc) use perforin and granzyme B (gzmB) to kill virus-infected cells and cancer cells. Recent evidence suggests that human gzmB primarily induces apoptosis via the intrinsic mitochondrial pathway by either cleaving Bid or activating Bim leading to the activation of Bak/Bax and subs...

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Vydáno v:J Biol Chem
Hlavní autoři: Catalán, Elena, Jaime-Sánchez, Paula, Aguiló, Nacho, Simon, Markus M., Froelich, Christopher J., Pardo, Julián
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358112/
https://ncbi.nlm.nih.gov/pubmed/25605735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.631564
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