Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion

Cytotoxic T cells (Tc) use perforin and granzyme B (gzmB) to kill virus-infected cells and cancer cells. Recent evidence suggests that human gzmB primarily induces apoptosis via the intrinsic mitochondrial pathway by either cleaving Bid or activating Bim leading to the activation of Bak/Bax and subs...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Catalán, Elena, Jaime-Sánchez, Paula, Aguiló, Nacho, Simon, Markus M., Froelich, Christopher J., Pardo, Julián
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358112/
https://ncbi.nlm.nih.gov/pubmed/25605735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.631564
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