Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart

AIMS: The NLRP3 inflammasome is activated in the ischaemic heart promoting caspase-1 activation, inflammation, and cell death. Ischaemic injury establishes both a priming signal (transcription of inflammasome components) and a trigger (NLRP3 activation). Whether NLRP3 activation, without priming, in...

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Bibliografiske detaljer
Udgivet i:Cardiovasc Res
Main Authors: Toldo, Stefano, Mezzaroma, Eleonora, McGeough, Matthew D., Peña, Carla A., Marchetti, Carlo, Sonnino, Chiara, Van Tassell, Benjamin W., Salloum, Fadi N., Voelkel, Norbert F., Hoffman, Hal M., Abbate, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357795/
https://ncbi.nlm.nih.gov/pubmed/25524927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu259
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