Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes

Huntington's Disease (HD) is caused by a polyglutamine tract expansion in huntingtin (HTT). Despite HTTs ubiquitous expression, there is early and robust vulnerability in striatum, the cause of which is poorly understood. Here, we provide evidence that impaired striatal mTORC1 activity underlie...

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Publicado en:Neuron
Autores principales: Lee, John H, Tecedor, Luis, Chen, Yong Hong, Monteys, Alex Mas, Sowada, Matthew J, Thompson, Leslie M, Davidson, Beverly L
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355620/
https://ncbi.nlm.nih.gov/pubmed/25556834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.019
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