Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes

Huntington's Disease (HD) is caused by a polyglutamine tract expansion in huntingtin (HTT). Despite HTTs ubiquitous expression, there is early and robust vulnerability in striatum, the cause of which is poorly understood. Here, we provide evidence that impaired striatal mTORC1 activity underlie...

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發表在:Neuron
Main Authors: Lee, John H, Tecedor, Luis, Chen, Yong Hong, Monteys, Alex Mas, Sowada, Matthew J, Thompson, Leslie M, Davidson, Beverly L
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355620/
https://ncbi.nlm.nih.gov/pubmed/25556834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.019
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