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Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes
Huntington's Disease (HD) is caused by a polyglutamine tract expansion in huntingtin (HTT). Despite HTTs ubiquitous expression, there is early and robust vulnerability in striatum, the cause of which is poorly understood. Here, we provide evidence that impaired striatal mTORC1 activity underlie...
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| Publicado no: | Neuron |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355620/ https://ncbi.nlm.nih.gov/pubmed/25556834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.019 |
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