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Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways
INTRODUCTION: Sclerostin is a Wnt inhibitor produced by osteocytes that regulates bone formation. Because bone tissue contributes to the development of osteoarthritis (OA), we investigated the role of sclerostin in bone and cartilage in a joint instability model in mice. METHODS: Ten-week-old SOST-k...
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| Publicat a: | Arthritis Res Ther |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355467/ https://ncbi.nlm.nih.gov/pubmed/25656376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0540-6 |
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