Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

OBJECTIVE: Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartilage metabolism. METHODS: OA was induced...

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Detalhes bibliográficos
Main Authors: Funck-Brentano, Thomas, Lin, Hilène, Hay, Eric, Ah Kioon, Marie-Dominique, Schiltz, Corinne, Hannouche, Didier, Nizard, Rémy, Lioté, Frédéric, Orcel, Philippe, de Vernejoul, Marie-Christine, Cohen-Solal, Martine Esther
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303845/
https://ncbi.nlm.nih.gov/pubmed/22432033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033543
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