Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

OBJECTIVE: Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartilage metabolism. METHODS: OA was induced...

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Hlavní autoři: Funck-Brentano, Thomas, Lin, Hilène, Hay, Eric, Ah Kioon, Marie-Dominique, Schiltz, Corinne, Hannouche, Didier, Nizard, Rémy, Lioté, Frédéric, Orcel, Philippe, de Vernejoul, Marie-Christine, Cohen-Solal, Martine Esther
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303845/
https://ncbi.nlm.nih.gov/pubmed/22432033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033543
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