Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

OBJECTIVE: Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartilage metabolism. METHODS: OA was induced...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Funck-Brentano, Thomas, Lin, Hilène, Hay, Eric, Ah Kioon, Marie-Dominique, Schiltz, Corinne, Hannouche, Didier, Nizard, Rémy, Lioté, Frédéric, Orcel, Philippe, de Vernejoul, Marie-Christine, Cohen-Solal, Martine Esther
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303845/
https://ncbi.nlm.nih.gov/pubmed/22432033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033543
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