Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

OBJECTIVE: Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartilage metabolism. METHODS: OA was induced...

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Main Authors: Funck-Brentano, Thomas, Lin, Hilène, Hay, Eric, Ah Kioon, Marie-Dominique, Schiltz, Corinne, Hannouche, Didier, Nizard, Rémy, Lioté, Frédéric, Orcel, Philippe, de Vernejoul, Marie-Christine, Cohen-Solal, Martine Esther
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303845/
https://ncbi.nlm.nih.gov/pubmed/22432033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033543
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