Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation

INTRODUCTION: Rheumatoid arthritis (RA) is characterized by bone and cartilage invasion by fibroblast-like synoviocytes (FLSs). Adrenomedullin, a peptide with anabolic and antiapoptotic properties, is secreted by rheumatoid FLSs. Adrenomedullin also increases the expression of adhesion molecules in...

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Main Authors: Ah Kioon, Marie-Dominique, Asensio, Carine, Ea, Hang-Korng, Uzan, Benjamin, Cohen-Solal, Martine, Lioté, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991025/
https://ncbi.nlm.nih.gov/pubmed/20942979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3160
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