Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

INTRODUCTION: Sclerostin is a Wnt inhibitor produced by osteocytes that regulates bone formation. Because bone tissue contributes to the development of osteoarthritis (OA), we investigated the role of sclerostin in bone and cartilage in a joint instability model in mice. METHODS: Ten-week-old SOST-k...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Arthritis Res Ther
Egile Nagusiak: Bouaziz, Wafa, Funck-Brentano, Thomas, Lin, Hilène, Marty, Caroline, Ea, Hang-Korng, Hay, Eric, Cohen-Solal, Martine
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355467/
https://ncbi.nlm.nih.gov/pubmed/25656376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0540-6
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