Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice

Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function. Here, we tested the effect of furin on chondrocyte catabolism and the developme...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lin, Hilène, Hay, Eric, Latourte, Augustin, Funck-Brentano, Thomas, Bouaziz, Wafa, Ea, Hang-Korng, Khatib, Abdel-Majid, Richette, Pascal, Cohen-Solal, Martine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041273/
https://ncbi.nlm.nih.gov/pubmed/29992982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28713-2
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados